Novel Substituted Monocyclic Heteroaryl Compounds for Treating Huntington’s Disease

Potential Vaccines for Treating Crohn\'s Disease

Crohn's disease (CD) is an inflammatory disease of the gastrointestinal tract (GIT) tract and can affect several parts of the digestive system. There is a relationship between impaired mucosal barrier in the GIT of inflammatory bowel disease patients and the role of bacteria such as Mycobacterium avium paratuberculosis in CD. Apart from different therapeutic approaches for treating CD, developm...

Method for Accessing Nitrogen-Containing, B-Heteroaryl-Substituted 2,1-Borazaronaphthalenes

The azaborine motif provides a mimic of aromatic systems through replacement of a C═C bond with a B-N bond. In particular, 2,1-borazaronaphthalenes, accessible through robust methods of synthesis and subsequent functionalization, afford an ideal platform to use for a variety of applications. However, the scope of substructures for this archetype has been limited by the lack of nitrogen-containi...

Applying Bioinfomatics Strategies in Huntingtons Disease Research

Heteroaryl substituted bis-trifluoromethyl carbinols as malonyl-CoA decarboxylase inhibitors.

A series of heteroaryl-substituted bis-trifluoromethyl carbinols were prepared and evaluated as malonyl-CoA decarboxylase (MCD) inhibitors. Some thiazole-based derivatives showed potent in vitro MCD inhibitory activities and significantly increased glucose oxidation rates in isolated working rat hearts.

Synthesis of 4- and 5- nitro-substituted heteroaryl cinnamoyl derivatives

In the condensation of the 4and 5-nitro-substituted 2-acetyl-1,3-indandione with heteroaryl aldehydes in the presence of alkaline or acidic catalysts, the corresponding cinnamoyl derivatives are obtained that possess anticoagulant activity, compared with that of 2-acetyl-1,3-indandione. It has been proven that some of the sodium salts of the cinnamoyl-indandione possess anticoagulant activity. ...